MST1R and neoplasm: Furthermore, overexpression of several molecular biomarkers is also associated with poor prognosis, e.g., macrophage-stimulating protein receptor (RON), related to tumor invasion, cyclo-oxygenase (COX)-2, expressed in malignant FMCs, and topoisomerase IIβ binding protein 1 (TopBP1), which is similar to BRAC2 in HBC [31,58].