MAPK8 and posterior cortical atrophy: The expression of BMPs by PCa was reported to induce osteoblast differentiation through both the canonical (Wnt/β-catenin) and noncanonical (Wnt/JNK) signaling pathways in C4-2B cells (PCa cell line), and Dkk-1 blocked the osteoblastic differentiation in vitro [36].