The combined action of Stx2 and SubAB can cause more serious kidney damage and the appearance of typical HUS features in humans such as partial or total deterioration of kidney function, erythrocyte alterations, increase of free hemoglobin, probably associated with microangiopathic hemolytic anemia [1,58], and even death. Here, STX2 is linked to congenital thrombotic thrombocytopenic purpura.