NOTCH1 and neoplasm: Woo et al. (2017) [114] have suggested that inflammatory signals are one of the most important factors to modulate chemoresistance and establish metastatic lesions, as was proved in tumor xenografts containing oral squamous cell carcinoma (OSCC) cells infected with P. gingivalis which showed greater resistance to paclitaxel (Taxol®) by activation of the Notch1 gene, as compared with tumor elicited with uninfected cells.