Furthermore, according to Ding et al. (2017) [72], the different isoforms of LPS also can affect periodontal pathogenesis by disrupting pattern recognition receptors (PRRs) like LPS-binding protein (LBP), helping a pathogen such as P. gingivalis to escape from host defenses, leading to persistent signs of periodontal disease. This evidence concerns the gene LBP and periodontal disorder.