LGALS3 and diabetes mellitus: Galectin-3 levels strongly correlated with eGFR decline in the Ludwigshafen Risk and Cardiovascular Health study and were even more markedly elevated in the German Diabetes Mellitus Dialysis study; it could also identify individuals at risk of developing CKD or rapidly losing renal function over time in the general population and patients with CKD or chronic systolic heart failure [12,13,18,19].