This observation, together with our experimental association of HlyA to the leaky gut with influx of noxious agents and to the pro-oncogenic PTEN inhibition as well as to the cell separation or even dissemination of colon carcinoma Caco-2 cells, could open new perspectives on the surveillance of these virulence factors in colorectal cancer and metastases. This evidence concerns the gene PTEN and colorectal cancer.