We observed that the GIP receptor antagonist GIP(3-30)NH2 can inhibit anorexia caused by exogenous GIP or DON, and the anorexia response induced by GLP-1 and DON can be effectively controlled by the GLP-1R antagonist Exendin(9-39) inhibition, which is consistent with previous studies [21]. The gene discussed is GLP1R; the disease is Anorexia.