While our studies are the first to formally describe (11) and mechanistically interrogate this potentially novel form of MYBPC1 myopathy, dominant missense variants in additional sarcomeric genes, including MYH2, MYH7, MYL2, TNNT1, TPM3, and NEB, also result in myopathy with tremor in the absence of obvious neuropathy (recently reviewed in ref. 37). The gene discussed is MYL2; the disease is myopathy.