Lastly, imaging and CSF analysis play a supportive role to further delineate a diagnosis of anti-LGI-1 antibody LE.6 Patients suspected of the disease will typically present with either an additional finding of a neoplastic mass, a confirmed anti-LGI-1 antibody on CSF encephalopathy-autoimmune evaluation, and/or an increased FLAIR hyperintense signaling in the medial temporal lobes on MRI (unilaterally or bilaterally).7 This evidence concerns the gene LGI1 and Encephalopathy.