(iii) we performed a population genetics analysis of the 48 functionally relevant variants in the ACE2, TMPRSS2 and BSG genes in human populations to detect particular patterns of between-population genetic differentiation and independently of evidence of genetic association between ACE2, TMPRSS2 and BSG variants and infectious diseases, using published and unpublished data from different worldwide populations (Table S1-B), enriched for Latin Americans, who are mainly the product of admixture of Native Americans, Europeans and Africans. This evidence concerns the gene TMPRSS2 and infectious disease.