To determine if the macrophage Soat1 alters atherosclerosis without an effect on plasma cholesterol, Fazio and Linton performed BMT from WT and Soat1−/− donor mice into Ldlr−/− host mice, and found larger aortic root and surface lesions in the mice receiving the Soat1−/− marrow [26]. Here, SOAT1 is linked to atherosclerosis.