TFF2 and obesity due to melanocortin 4 receptor deficiency: In addition, the Tff2 KO resulting in an increased metabolic activity of both lipids and glucose in the mice (that ultimately led to the protection from the HF diet-induced obesity) points TFF2 as a lipid anabolic (and possibly a carbohydrates conversion into lipids) factor and explains the reduced adiposity in Tff2 KO mice.