LPL and metabolic syndrome: LPL function is further regulated by adipokines and other signaling molecules such as angiopoietin-like proteins (ANGPTLs) [82] and apolipoproteins including Apo-A5 [83], and there are findings that the gut microbiota and its metabolites influence these and in such a way regulate LPL-mediated lipolysis, causing shifts in triglyceride (TG) trafficking and subsequent dyslipidemia, as is summarized in Figure 2A.