The mechanisms contributing to dyslipidemia in the obese include exaggerated synthesis of very low density lipoprotein (VLDL) by the liver, impairment of lipoprotein lipase (LPL) and lipolysis, LDL-receptor downregulation, reductions in HDL-C, and its related changes in neutral lipid transfer by enzymes such as CETP and phospholipid transfer protein (PTP) [34,48]. The gene discussed is CETP; the disease is metabolic syndrome.