Cai et al. reported that L. plantarum FRT10 supplementation alleviated HFD-induced obesity in mice partly related to the activation of the peroxisome proliferator-activated receptor-α (PPARα)/carnitine palmitoyltransferase-1α (CPT1α) pathway [110]. This evidence concerns the gene CPT1A and obesity due to melanocortin 4 receptor deficiency.