NeoBaseTM 2 tests for more than 50 analytes, including the markers of adenosine deaminase severe combined immunodeficiency (ADA-SCID) and X-linked adrenoleukodystrophy (X-ALD), following a fast extraction procedure that allows also for the yield of diketones (e.g., succinylacetone). This evidence concerns the gene ADA and severe combined immunodeficiency.