F2 and acute respiratory distress syndrome: During ECMO, due to both ARDS pathogenesis [17,41] and the continuous contact surface between the blood and the ECMO circuit [18], different coagulative pathways were also regulated by F2, FN1, MPL, and TBXA2R protein (which are known as positive regulators of these pathways) [18,42,43,44] and tissue factor pathway inhibitor (TFPI) (a negative regulator of coagulation processes) [45].