In the course of our search for natural PPAR agonists, eight 2,5-DKPs (1–8) were isolated from the jellyfish-derived fungus A. flavus. Compound 8 was selected as a partial PPAR-γ agonist and evaluated for neuroprotective effect using SH-SY5Y neuroblastoma cells. Here, PPARG is linked to neuroblastoma.