APOE and Cognitive impairment: For example, epidemiological studies underlined that daily consumption of seaweed and ω-3 polyunsaturated fatty acids (PUFA) can slow down cognitive deficit in apolipoprotein E (apoE) carriers [15], which is in line with a meta-analysis conclusion that 0.1 g/day increment of dietary docosahexaenoic acid (DHA; 1) intake was associated with lower risks of dementia [16].