After adjusting for age, obesity, current smoking, current drinking, physical activity, total caloric intake, MBP, plasma glucose, serum CRP, baseline serum LDL cholesterol levels, and taking anti-dyslipidemic medication at baseline, the adjusted HRs and 95% CI for the incidence of non-achievement of LDL cholesterol targets for the T2 and T3 tertiles vs. the referent T1 tertile were 1.56 (1.29–1.90) and 1.86 (1.47–2.31) in men and 1.40 (1.18–1.66) and 1.31 (1.06–1.62) in women, respectively. The gene discussed is CRP; the disease is obesity due to melanocortin 4 receptor deficiency.