The persistent ductus arteriosus has been associated with chromosomal abnormalities in 10% of the cases and TGFBeta signaling abnormalities, as in Marfan or Loeys Dietz, to TFAP2B in Char syndrome and to TFAP2B, TNF-RAF1, prostacyclin synthase in premature and term infants [31,34]. Here, TFAP2B is linked to Char syndrome.