H19 and cardiac hypertrophy: Another lncRNA shown to be important in pressure overload models of cardiac hypertrophy is H19. Viereck et al. found H19 to be downregulated during pathological cardiac hypertrophy in mice, pigs, human engineered heart tissue (hEHT) subjected to afterload, and in human tissue from various cardiac diseases including hypertrophic cardiomyopathy [52].