In addition, using a Math1-Cre/Ptch1fl/fl/Nestin-CFP mouse model, in which medulloblastoma cells gradually increase the level of Nestin, an intermediate filament protein that plays an inhibitory function on GLI3, these authors showed that the SHH protein was able to induce the production of Nestin mRNA in these mice via tumor-associated astrocytes (TAAs) [29,78]. Here, NES is linked to neoplasm.