SOX2 is involved in many signaling pathways such as VEGF, MAPK, Notch, P53, Wnt, and JakSTAT, and regulates the expression of many genes, which are very important regulators of CSCs and contribute to proliferation, migration, and invasion of cancer cells, thereby affecting cancer progression, prognosis, and resistance to anticancer therapies [33]. Here, TP53 is linked to cancer.