AR and extramammary Paget disease: Although most EMPD cases exhibit low expression of estrogen receptor (ER), EPMD shows a high androgen receptor (AR)-positive rate at 54–90%, and AR expression was stronger in invasive EMPD than in situ EMPD [61,62,63], indicating that AR signaling may be involved in the EMPD progression and that blockade of AR signaling might be another effective therapy for EMPD.