PDCD1LG2 and neoplasm: In this study, both PD-L1 and PD-L2 expression, as well as low CD8+ tumor-infiltrating T-cell (TIL) numbers, were associated with shorter postoperative recurrence-free survival, suggesting that the expression of PD-L1/PD-L2 in tumor cells may be a factor for worse prognosis [84].