PRKDC and cancer: These include the gene encoding for the ubiquitin ligase FBXW7, which is mutated in 18.4% of 3q26-amplified and in 10.5% of non-amplified cancers, and the gene encoding for the catalytic sub-unit of DNA-activated protein kinase PRKDC, which is mutated in 15.8% of 3q26-amplified and in 6.2% of non-amplified cancers (Figure 3).