Urinary EVs (uEVs) have attracted attention because they contain various types of renal functional proteins derived from specific and different regions of the nephron, including Na+/H+ exchanger isoform 3, aquaporin 1 (AQP1), AQP2, sodium‐potassium‐chloride co‐transporter 2, and sodium‐chloride cotransporter, suggesting that these renal proteins in uEVs could provide information on renal disease states (Gonzales et al., 2009; Oshikawa et al., 2016; Pisitkun et al., 2006). Here, AQP2 is linked to kidney disorder.