AQP2 and chronic kidney disease: As the AUC values for uEV‐AQP1, ‐AQP2, and ‐TSG101 for patients with CKD G4 and G5 were high (>0.8) (El Khouli et al., 2009; Metz, 1978), in order to check whether the combination of these proteins would yield better accuracy than for each protein alone, we employed a multiple logistic regression model.