TNF and in situ carcinoma: In contrast, the RV had relatively unchanged inflammatory mediator expression with no change at 8 h of CIS compared to baseline for NLRP3 (p = 0.174), cleaved p17‐IL‐1β (p = 0.811), TNFα (p = 0.749), IL‐6 (p = 0.259), MCP1 (p > 0.999), and IL‐10 (p = 0.985).