Based on sequence homology, histone deacetylase 8 (HDAC8) is one of the class I HDAC enzymes, which plays important roles in parasitic/viral infections, tumorigenesis, neuronal disorders, smooth muscle contraction, skull morphogenesis, telomere protection and cohesin dynamics.12, 13, 14, 15, 16, 17. Here, HDAC8 is linked to viral infectious disease.