Furthermore, myocardial 8-isoprostane levels were significantly increased (Fig. 8b), with trends towards an increase in myocardial NOX2 expression (Fig. 8c) and sNOX-dp in plasma (Supplementary Fig. 10), and a significantly lower total anti-oxidant capacity in DM + HFD + CKD swine (Fig. 8d). Here, CYBB is linked to chronic kidney disease.