While the levels of ß-amyloid and tau-pathology can be determined using cerebro-spinal fluid (CSF), plasma, and molecular imaging methods [12], determining the degree of neurodegeneration (as defined in the ATN framework) remains challenging and 7-T magnetic resonance imaging could provide a substantial advantage over MRI at 1.5 or 3 T. In addition to assessing neurodegeneration, 7-T imaging provides innovative readouts for vascular pathology occurring either as a consequence of AD or as a comorbidity, for dysfunction of macro- and mesoscale neural networks and for molecular pathology. This evidence concerns the gene MAPT and Alzheimer disease.