In these mice, hearing loss was found to promote schizophrenia-relevant brain and behavioural abnormalities, including altered electrophysiological measurements of central auditory gain, and was associated with a smaller number of parvalbumin inhibitory neurons in the auditory cortex than were found in Df1/ + mutant mice with no hearing loss (Zinnamon et al. 2019). The gene discussed is YTHDF1; the disease is schizophrenia.