Indeed, our preliminary findings indicate that in 8-week post-myocardial infarction mouse model of heart failure, mRNA protein expression levels of ClC-2 and ClC-3 mechanosensitive chloride channels are significantly downregulated within the intercaval region of the right atrium, which correlates with a significantly enhanced cardiomyocyte membrane tension and downregulation of caveolae structures (194). This evidence concerns the gene CLCN3 and heart failure.