Loss of wild-type RUNX1 significantly reduces cell proliferation in CBFB-MYH11 fusion-induced leukemia cells (Hyde et al., 2015), E2A-PBX1-induced ALL (Pi et al., 2020), and MLL-fusion-induced AML (Milne et al., 2002). Here, RUNX1 is linked to acute myeloid leukemia.