TNFRSF1B and osteoporosis: Previous studies have shown that PT extracts can reverse glucocorticoid-induced spinal osteoporosis in rats via targeting osteoblastic and osteoclastic markers (An et al., 2016); PT extracts have also been shown to promote BMSCs proliferation and osteogenic differentiation by regulating Let-7f-5p and the TNFR2/PI3K/AKT signaling pathway (Liang et al., 2016).