DSG1 and pemphigus: Therefore, this pathway represents a very important crossing point between Dsg3- and Dsg1-dependent signalling and a protective role of Dsg1 against signalling induced by anti-Dsg3 autoantibodies in pemphigus can explain why in mucosal PV the epidermis is not affected although Dsg3 distribution is severely altered (149, 178, 179).