DSG3 and pemphigus: To delineate the role of p38MAPK in pemphigus pathogenesis it was shown that specific inhibition of p38MAPK or its downstream target MAPKAPK2 are sufficient to reduce loss of adhesion in keratinocytes in vitro (221, 247), depletion of both extra- and intradesmosomal Dsg3 (132, 233, 244) from both the soluble and insoluble fractions (132) and the activation of and reorganisation of the cytoskeleton by HSP27 (237) upon PV-IgG treatment.