GSNO has been shown to promote the S-nitrosation of catalase, which modulates its activity in processes like growth, development and response to stress in plants (Corpas et al., 2019) and animals (Tyther et al., 2007), and GSNO-directed inhibition of catalase by S-nitrosation has been linked to obesity in humans (Palma et al., 2020). The gene discussed is CAT; the disease is obesity due to melanocortin 4 receptor deficiency.