Current notion suggested that ING2 might act as one crucial player in the pathogenesis of several tumors, such as non-small cell lung carcinoma, head and neck squamous cell carcinoma, and hepatocellular carcinoma, and serve as a potential pharmacologic target for these cancers as well (Zhang et al., 2008; Borkosky et al., 2009; Ythier et al., 2010; Guerillon et al., 2013). The gene discussed is ING2; the disease is head and neck squamous cell carcinoma.