After excluding TNFRSF6B for its low expression, a total of 59 CMGs were abstracted from The Cancer Genome Atlas (TCGA) HNSCC data, including 13 well-defined B7-CD28 family costimulatory molecules and 46 TNFRSF family costimulatory molecules (Table 2). The gene discussed is TNFRSF6B; the disease is head and neck squamous cell carcinoma.