A proteomic study (Magherini et al., 2018) on the effect of Gold (I)-N-heterocyclic carbene compounds on tumor cell proliferation showed that Au(NHC) and Au(NHC)2 (Figure 1S), both of them can inhibit glucose uptake and reduce oxygen consumption of A2780 cells, the latter can also inhibit mitochondrial respiration coupled with a decrease of citrate synthase (CS) amount, the rate-limiting enzyme of TCA cycle. This evidence concerns the gene CS and neoplasm.