HK2 and neoplasm: C-Myc can drive glycolysis; upregulate lactate dehydrogenase A (LDHA), hexokinase 2 (HK2), and pyruvate kinase M2 (PKM2); improve the transcription rate of glucose transporter (GLUT); regulate the transcription of monocarboxylate transporters (MCT); and promote tumor growth (Kim et al., 2007; Dang et al., 2009).