Novel biomarkers such as Neutrophil gelatinase-associated lipocalin (NGAL), cystatin C, Interleukin-6 (IL-6) and Fibroblast Growth Factor (FGF-23) can improve the early diagnosis of AKI and CKD (193–197), predict clinical outcome (198, 199) and help quantitation of severity in CKD (200). This evidence concerns the gene IL6 and chronic kidney disease.