ITGAM and glioblastoma: The use of scRNA-seq to elucidate the gene signatures of CD11b-positive cells from GBM biopsies revealed that individual cells frequently coexpressed of both pro-inflammatory M1 and immune suppressive M2 macrophage genes (42), suggesting that the distinct partitioning of the M1/M2 macrophage subtypes is inadequate to completely represent the TAM expression profiles in GBM (43).