IL6 and cancer: Differently, CAF-secreted IL6, CXCL9, and TGFβ reduce T cell response to cancer cells, especially cytotoxic T cells (90), whereas CAF-mediated production of CXCL12 (91) and inactivation of focal adhesion kinase in cancer cells (92) amplify antitumor effects through diminishing stromal fibroblast activation.