Using a pool of circRNAs to screen ESCC identifies that upregulation of circ-DLG1 and circ-TTC17 combining with downregulation of hsa_circ_0001946, hsa_circ_0062459 and circ-SMAD7 has 79% sensitivity and 85% specificity, in which positive samples in this pool test have 5-fold higher possibility in transition to ESCC than normal controls (263). The gene discussed is DLG1; the disease is esophageal squamous cell carcinoma.