To suppress tumor growth, TGFβ arrests cell cycle through inhibiting cyclin dependent kinase and c-Myc pathways (103), induces cell apoptosis through activating JNK and Fas pathway, and antagonizing Bcl-2, Bcl-X, and survivin (104), and eventually prevents cell immortalization through regulating reverse transcriptase activity of human telomerase (105). Here, TGFB1 is linked to neoplasm.