TGFB1 and cancer: The dual roles of TGFβ showing at early and advanced stage of cancers are not due to the change of TGFβ structure, but are mediated through mutant TGFβ receptors as well as interaction of cancer cell-secreted TGFβ with the whole stromal cells such as dendritic cells, T cells, NK cells, TAMs, CAFs, and MDSCs.