In addition to having normal physiological functions, TDP-43 is closely related to amyotrophic lateral sclerosis (ALS), frontotemporal lobar dementia (FTLD), Alzheimer’s disease (AD), Parkinson’s disease (PD) and other neurodegenerative diseases (Gao et al., 2019). The gene discussed is TARDBP; the disease is amyotrophic lateral sclerosis.