Martin-Sanchez et al. (2017) showed that IL-33 release is related to ferroptosis, and ferroptosis in acute kidney injury may regulate inflammation by activating IL-33.However, the relationship between ferroptosis in cancer and IL-33 is not clear.Previous studies have reported that CD8 + T cells induce ferroptosis of tumor cells in vivo (Wang et al., 2019; Tang et al., 2020). The gene discussed is IL33; the disease is acute kidney injury.