Furthermore, some drugs, such as dendrobium officinale polysaccharides, could also display remarkable anti-inflammation and hepatoprotective effects via the TLR4/NF-κB signaling pathway (Yang et al., 2020), which indicated that ischemia-reperfusion injury is related to the activation of the TLR4/NF-κB signaling pathway. This evidence concerns the gene TLR4 and ischemia.