IGFBP5 and central nervous system cancer: Three mRNAs were identified as oncogenes in gliomas, which was consistent with our multivariate Cox regression analysis result: IGFBP5 can increase cell invasion and inhibit cell proliferation via the EMT and Akt signaling pathways in GBM (Dong et al., 2020); IP6K2 was reported to promote cell proliferation and inhibit cell apoptosis under the regulation of the LINC00467/miR-339-3p axis (Liang & Tang, 2020); and KPNA4 is capable of facilitating epithelial-mesenchymal transition in glioma, which can be suppressed by miR-181b, a tumor-suppressive miRNA (Wang et al., 2015).