EGFR and neoplasm: In gliobastomas, IGFBP2 affects a myriad of different molecular networks and shaping tumor progression by unbalancing the EGFR-STAT3 signaling and potentiating STAT3 phosphorylation [14], connecting integrins and NF-κB signaling to cell migration [31], and promoting tumor cell trans-differentiation into endothelial cells (vasculogenic mimicry) via expression of vascular-endothelial cadherin CD144 and MMP2 [15].