TRIM58 and neoplasm: It was also observed that TRIM58 was negatively correlated with the mTORC1 signaling pathway (P<0.001; FDR<0.001; NESLUSC=−2.61; P<0.001; FDR<0.001; NESLUAD=−2.32) (Fig. 4C and F), further indicating a tumor suppressor role of TRIM58.