The entries were divided into five categories: biochemical substances involved in cancer (proteoglycans and central carbon metabolites), pathways in cancer, human diseases associated with cancer (pancreatic cancer, prostate cancer, colorectal cancer, chronic myeloid leukaemia, and nonsmall-cell lung cancer and glioma), signal transduction pathways (Ras, oestrogen, FoxO, prolactin, Rap1, PI3K-Akt, insulin, PPAR, and thyroid hormone signalling pathways); and types of cell junctions (adherens junctions). Here, INS is linked to central nervous system cancer.