Notably, interventional therapy, although it can substantially prolong the survival time of patients, cannot eliminate all cancer cells, and residual cells in hypoxic and ischemic conditions elevate the expression of the hypoxia inducible factor, which can increase VEGF transcription and then accelerate the frequency of neoangiogenesis, so that patients are prone to recurrence and metastasis of liver cancer. The gene discussed is VEGFA; the disease is liver cancer.